What is rbe

Which is the result of damage to relative biological effectiveness? Pollution is any change in physical, chemical or biological charecteristics of the environment that has the potentiality to harm human life, life of other desirable species, natural resources, cultural assests and industries.

Thus pollution results in damage to biological effectiveness. What does RBE stand for? What is low LET radiation? Radiation is classified as either high linear energy transfer high LET or low linear energy transfer low LET , based on the amount of energy it transfers per unit path length it travels.

This is a direct consequence of the fact that the dose-response curve for low-LET radiations has a broader shoulder than for high-LET radiations. What is radiation weighting factor?

A radiation weighting factor is an estimate of the effectiveness per unit dose of the given radiation relative a to low-LET standard. Gy does not describe the biological effects of the different radiations. What is linear energy transfer in radiation? In dosimetry, linear energy transfer LET is the amount of energy that an ionizing particle transfers to the material traversed per unit distance. We note that the RBE is dependent upon many factors such as the fractionization of the radiation, dose level, end-point quantified for the damage e.

LD , and the biological specimen i. In this figure we can see an example i. When radiation dose is calculated there is a conversion factor based on the type of radiation.

These radiation weighting factors convert from equivalent dose to effective dose. The difference in radiation damage for the same dose described here by the LET and RBE is the reason that weighting factors are needed for different types of radiation. Since x-rays are low LET and used as the reference for RBE calculations it is clear why the weighting factor to convert from equivalent dose to effective dose is just 1.

Relative Biologic Effect RBE provides a method to compare how damaging different types of radiation are, given the same dose, and it is calculated using x-rays as a reference type of radiation. When x-rays go through the human body, the primarily interactions are via the Compton and Photoelectric effects. These interactions both produce energetic electrons that can cause damage to the body. Damage to the DNA is caused by direct action of the electrons, or indirect action of Free Radicals as discussed above.

About two-thirds of the damage is caused by indirect action. When there is local oxygen, the damage cannot be repaired as easily and thus is said to be fixed. Don't keep it to yourself!

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